Immune determinants of pegivirus persistence, control, and cross-species infection in the laboratory mouse

Abstract excerpt

<h4>ABSTRACT</h4> Approximately 15% of the global human population is viremic with human pegivirus (HPgV), a +ssRNA virus in the Flaviviridae family. An unusual feature of HPgV is its ability to persistently infect individuals without causing overt disease or evoking robust immune responses, but this phenomenon is poorly understood due to a dearth of systems for studying HPgV. In this study, we create the first...

Topics

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• Acquired Immunodeficiency Syndrome
• Bone Marrow
• Cytomegalovirus and herpesvirus research
• Flaviviridae Infections
• Hepatitis B Virus Studies
• Hepatitis C virus research
• HIV Research and Treatment
• Viral-associated cancers and disorders

Identifiers and source

Literature Corpus work

45d19c6a-7038-5b99-a704-c12b55944691

DOI

10.1101/2024.02.27.582314