Article

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury

2022-12-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> To elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic osteoarthritis (PTOA). <h4>Methods</h4> Male and female 12-week-old C57Bl/6 mice were randomized to noninvasive ACLR or sham (n=9/sex/group/timepoint). Knee hyper...

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Literature Corpus work: 21fca916-0062-575e-85b2-df220d9e8ea3
DOI: 10.1101/2022.11.30.517736

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