Back to search

Article

Development of primary osteoarthritis during aging in genetically diverse UM- HET3 mice

2024-01-22

Abstract excerpt

<title>Abstract</title> <p>Background Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various joint tissues undergo gradual change, including degeneration of the articular cartilage, alterations in subchondral bone (SCB) morphology, and inflammation of the synovium. Metho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ce98cf3d-1409-5733-979d-4f8fd51a3f55
DOI
10.21203/rs.3.rs-3858256/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Development of primary osteoarthritis during aging in genetically diverse UM- HET3 miceDOI 10.21203/rs.3.rs-3858256/v1
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 miceSemantic proximity
Current understanding of osteoarthritis pathogenesis and relevant new approachesSemantic proximity
Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research.Semantic proximity
How are Aging and Osteoarthritis Related?Semantic proximity
In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice.Semantic proximity
Age-associated spontaneous activation of BMP signaling inhibits the canonical Wnt pathway through ICAT to promote osteoarthritisSemantic proximity
Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female miceSemantic proximity
Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics.Semantic proximity
Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis ModelSemantic proximity
Differential patterns of pathology in and interaction between joint tissues in long-term osteoarthritis with different initiating causes: phenotype matters.Semantic proximity
Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis featuresSemantic proximity
Osteoarthritis: New Insights in Animal ModelsSemantic proximity
Select a neighboring publication to make it the new centre.