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Article

Germline-encoded specificities and the predictability of the B cell response.

PLoS pathogens - 1 Aug 2023

Vieira Marcos C, Palm Anna-Karin E, Stamper Christopher T, Tepora Micah E, Nguyen Khoa D, Pham Tho D, Boyd Scott D, Wilson Patrick C, Cobey Sarah

Abstract excerpt

Antibodies result from the competition of B cell lineages evolving under selection for improved antigen recognition, a process known as affinity maturation. High-affinity antibodies to pathogens such as HIV, influenza, and SARS-CoV-2 are frequently reported to arise from B cells whose receptors, the precursors to antibodies, are encoded by particular immunoglobulin alleles. This raises the possibility that the...

Topics

Animals
Mice
COVID-19
SARS-CoV-2
Antibodies
Alleles
Germ Cells

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37624867
DOI: 10.1371/journal.ppat.1011603
PMCID: PMC10484431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-37624867-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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