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Article

The evolution within us

20 Jul 2015

Abstract excerpt

The B-cell immune response is a remarkable evolutionary system found in jawed vertebrates. B-cell receptors, the membrane-bound form of antibodies, are capable of evolving high affinity to almost any foreign protein. High germline diversity and rapid evolution upon encounter with antigen explain the general adaptability of B-cell populations, but the dynamics of repertoires are less well understood. These...

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PMID: 26194749
DOI: 10.1098/rstb.2014.0235

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