Article
The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Sept 2015
Yaari Gur, Benichou Jennifer I C, Vander Heiden Jason A, Kleinstein Steven H, Louzoun Yoram
Abstract excerpt
During the several-week course of an immune response, B cells undergo a process of clonal expansion, somatic hypermutation of the immunoglobulin (Ig) genes and affinity-dependent selection. Over a lifetime, each B cell may participate in multiple rounds of affinity maturation as part of different immune responses. These two time-scales for selection are apparent in the structure of B-cell lineage trees, which...
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