Article
The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Sept 2015
Yaari Gur, Benichou Jennifer I C, Vander Heiden Jason A, Kleinstein Steven H, Louzoun Yoram
Abstract excerpt
During the several-week course of an immune response, B cells undergo a process of clonal expansion, somatic hypermutation of the immunoglobulin (Ig) genes and affinity-dependent selection. Over a lifetime, each B cell may participate in multiple rounds of affinity maturation as part of different immune responses. These two time-scales for selection are apparent in the structure of B-cell lineage trees, which...
Topics
- Antibody Affinity
- Antibody Diversity
- B-Lymphocytes
- Cell Lineage
- Clonal Selection, Antigen-Mediated
- Complementarity Determining Regions
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Models, Genetic
- Models, Immunological