Article

IZUMO1 is a sperm fusogen

2022-02-03

Abstract excerpt

<h4>Summary</h4> Mammalian sperm-egg adhesion depends on the trans-interaction between the sperm-specific type I glycoprotein IZUMO1 and its oocyte-specific GPI-anchored receptor JUNO. However, the mechanisms and proteins (fusogens) which mediate the following step of gamete fusion remain unknown. Using live imaging and content mixing assays in a heterologous system and structure-guided mutagenesis, we unveil an...

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Literature Corpus work: e4b05450-99f8-54f9-bc91-15c6f5b84622
DOI: 10.1101/2022.02.01.478669

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