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Article

TMEM95 is a sperm membrane protein essential for mammalian fertilization

2 Jun 2020

Abstract excerpt

The fusion of gamete membranes during fertilization is an essential process for sexual reproduction. Despite its importance, only three proteins are known to be indispensable for sperm-egg membrane fusion: the sperm proteins IZUMO1 and SPACA6, and the egg protein JUNO. Here we demonstrate that another sperm protein, TMEM95, is necessary for sperm-egg interaction. TMEM95 ablation in mice caused complete...

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PMID: 32484434
DOI: 10.7554/elife.53913

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