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Article

Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.

Nature - 23 Jun 2016

Ohto Umeharu, Ishida Hanako, Krayukhina Elena, Uchiyama Susumu, Inoue Naokazu, Shimizu Toshiyuki

Abstract excerpt

Fertilization is a fundamental process in sexual reproduction, creating a new individual through the combination of male and female gametes. The IZUMO1 sperm membrane protein and its counterpart oocyte receptor JUNO have been identified as essential factors for sperm-oocyte interaction and fusion. However, the mechanism underlying their specific recognition remains poorly defined. Here, we show the crystal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27309808
DOI: 10.1038/nature18596

Genes

IZUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.PMID 27309808Read ↗

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