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Sperm-Egg Interaction

2 Mar 2011

Abstract excerpt

A crucial step of fertilization is the sperm-egg interaction that allows the two gametes to fuse and create the zygote. In the mouse, CD9 on the egg and IZUMO1 on the sperm stand out as critical players, as Cd9(-/-) and Izumo1(-/-) mice are healthy but infertile or severely subfertile due to defective sperm-egg interaction. Moreover, work on several nonmammalian organisms has identified some of the most...

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PMID: 22054237
DOI: 10.1146/annurev-physiol-020911-153339

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