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Article

Sperm induction of somatic cell-cell fusion as a novel functional test

24 Jan 2024

Abstract excerpt

The fusion of mammalian gametes requires the interaction between IZUMO1 on the sperm and JUNO on the oocyte. We have recently shown that ectopic expression of mouse IZUMO1 induces cell-cell fusion and that sperm can fuse to fibroblasts expressing JUNO. Here, we found that the incubation of mouse sperm with hamster fibroblasts or human epithelial cells in culture induces the fusion between these somatic cells and...

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PMID: 38265078
DOI: 10.7554/elife.94228

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