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Article

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.

Nature communications - 15 Jul 2016

Kato Kazuki, Satouh Yuhkoh, Nishimasu Hiroshi, Kurabayashi Arisa, Morita Junko, Fujihara Yoshitaka, Oji Asami, Ishitani Ryuichiro, Ikawa Masahito, Nureki Osamu

Abstract excerpt

Sperm-egg fusion is the critical step in mammalian fertilization, and requires the interaction between IZUMO1 on the sperm surface and JUNO (also known as folate receptor (FR) 4 or IZUMO1R) on the egg surface. Whereas other FRs bind and uptake folates, JUNO binds IZUMO1 and establishes the cell-cell adhesion. However, the mechanism of IZUMO1 recognition by JUNO has remained elusive. Here we report the crystal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27416963
DOI: 10.1038/ncomms12198
PMCID: PMC4947182

Genes

IZUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.PMID 27416963Read ↗

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