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MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

7 Sept 2022

Abstract excerpt

Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg...

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PMID: 36070373
DOI: 10.1126/sciadv.abn0047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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