Article

Piccolo Regulates Secretion of the Extracellular Matrix Components Brevican and Tenascin R from Astrocytes to Drive Synapse Formation: Implications for Pontocerebellar Hypoplasia Type 3 (PCH3)

2025-07-03

Abstract excerpt

<h4>Background</h4> Astrocytes are crucial for CNS health, for instance via the secretion of extracellular matrix (ECM) components that are vital for synapse formation and maturation. While the scaffolding protein Piccolo is known for its role at synapses, its function in astrocytes and contribution to neurodegenerative disorders like Pontocerebellar Hypoplasia Type 3 (PCH3) are largely unknown. Understanding the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e49ce5c3-b987-51df-b173-819da86d8710
DOI: 10.1101/2025.07.03.662734

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Piccolo Regulates Secretion of the Extracellular Matrix Components Brevican and Tenascin R from Astrocytes to Drive Synapse Formation: Implications for Pontocerebellar Hypoplasia Type 3 (PCH3)DOI 10.1101/2025.07.03.662734Read

Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypesSemantic proximity Read

Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes.Semantic proximity Read

Sparse Neuronal C4 Elevation Induces Network-Wide Transcriptomic and Lipid-Droplet Remodeling in the Cortical MicroenvironmentSemantic proximity Read

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.Semantic proximity Read

Astrocyte extracellular matrix modulates neuronal dendritic developmentSemantic proximity Read

Astrocytic Regulation of aberrant perineuronal net formation in <i>Mecp2</i> -null NeocortexSemantic proximity Read

<i>NEUROG2</i> regulates a human-specific neurodevelopmental gene regulatory programSemantic proximity Read

A cellular and spatial map of the choroid plexus across brain ventricles and agesSemantic proximity Read

Dysregulation of astrocyte extracellular signaling in Costello syndrome.Semantic proximity Read

Sialylated Gangliosides are Required for Plasma Membrane Organization and Neuronal FunctionSemantic proximity Read

Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic SignaturesSemantic proximity Read

Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF.Semantic proximity Read