Article
Dysregulation of astrocyte extracellular signaling in Costello syndrome.
Science translational medicine - 6 May 2015
Krencik Robert, Hokanson Kenton C, Narayan Aditi R, Dvornik Jill, Rooney Gemma E, Rauen Katherine A, Weiss Lauren A, Rowitch David H, Ullian Erik M
Abstract excerpt
Astrocytes produce an assortment of signals that promote neuronal maturation according to a precise developmental timeline. Is this orchestrated timing and signaling altered in human neurodevelopmental disorders? To address this question, the astroglial lineage was investigated in two model systems of a developmental disorder with intellectual disability caused by mutant Harvey rat sarcoma viral oncogene homolog...
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