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Article

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

Nature - 1 Apr 2023

Soto Joselyn S, Jami-Alahmadi Yasaman, Chacon Jakelyn, Moye Stefanie L, Diaz-Castro Blanca, Wohlschlegel James A, Khakh Baljit S

Abstract excerpt

Astrocytes and neurons extensively interact in the brain. Identifying astrocyte and neuron proteomes is essential for elucidating the protein networks that dictate their respective contributions to physiology and disease. Here we used cell-specific and subcompartment-specific proximity-dependent biotinylation1 to study the proteomes of striatal astrocytes and neurons in vivo. We evaluated cytosolic and plasma...

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Identifiers

PMID: 37046092
DOI: 10.1038/s41586-023-05927-7
PMCID: PMC10132990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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