Article

Leveraging Large-Scale Biobanks for Therapeutic Target Discovery

2025-02-12

Abstract excerpt

Large biobanks, including the Million Veteran Program (MVP), the UK Biobank, and FinnGen, provide genetic association results for more than 1,000,000 individuals for hundreds of phenotypes. To select targets for pharmaceutical development, as well as to improve the understanding of existing targets, we harmonized these studies, and performed two-sample Mendelian Randomization (MR) on 2,003 phenotypes using genetic...

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Literature Corpus work: e4952bed-0bdd-5218-a21b-d0c40568aa3e
DOI: 10.1101/2025.02.10.25321487

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