Back to search

Article

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

2020-11-11

Abstract excerpt

Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter its expression or function, as a tool to anticipate the effect of drug action on the same target. Here, we applied MR to prioritize drug targets for their causal relevance for coronary heart disease (CHD). The targets were further prioritized using genetic co-localization, protein express...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cce0de3f-8fce-5e28-bb27-7dc62b648f65
DOI
10.1101/2020.11.11.377747
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human geneticsDOI 10.1101/2020.11.11.377747
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human geneticsSemantic proximity
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human geneticsSemantic proximity
Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart diseaseSemantic proximity
A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular diseaseSemantic proximity
Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis.Semantic proximity
Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomizationSemantic proximity
Target Discovery for Drug Development Using Mendelian Randomization.Semantic proximity
From lipid locus to drug target through human genomics.Semantic proximity
Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisationSemantic proximity
Leveraging human genetics to guide drug target discovery.Semantic proximity
Association of genetically predicted lipid traits and lipid-modifying targets with heart failureSemantic proximity
Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity
Select a neighboring publication to make it the new centre.