Article

Open Targets Genetics: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

2020-09-17

Abstract excerpt

Genome-wide association studies (GWAS) have identified many variants robustly associated with complex traits but identifying the gene(s) mediating such associations is a major challenge. Here we present an open resource that provides systematic fine-mapping and protein-coding gene prioritization across 133,441 published human GWAS loci. We integrate diverse data sources, including genetics (from GWAS Catalog and U...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 425d1876-ff13-5288-b429-c6f43b0d3a4f
DOI: 10.1101/2020.09.16.299271

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Open Targets Genetics: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated lociDOI 10.1101/2020.09.16.299271Read

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.Semantic proximity Read

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.Semantic proximity Read

Benchmarking genome-wide association study causal gene prioritization for drug discoverySemantic proximity Read

From genetic associations to genes: methods, applications, and challenges.Semantic proximity Read

Genetic associations of protein-coding variants in human diseaseSemantic proximity Read

Genetic associations of protein-coding variants in human disease.Semantic proximity Read

TargetGene: a comprehensive database of cell-type-specific target genes for genetic variants.Semantic proximity Read

GWASdb v2: an update database for human genetic variants identified by genome-wide association studies.Semantic proximity Read

Combining SNP-to-gene linking strategies to pinpoint disease genes and assess disease omnigenicitySemantic proximity Read

From variant to drug target: using the expanded Open Targets Platform to explore the genetics of target discoverySemantic proximity Read

Integration of genetic evidence to identify approved drug targetsSemantic proximity Read

webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study.Semantic proximity Read