Article

Mendelian randomization for studying the effects of perturbing drug targets

2021-02-10

Abstract excerpt

Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be used in Mendelian randomization analyses to offer insight into mechanism-based efficacy and adverse effects. Large databases of summary level genetic association data a...

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Identifiers and source

Literature Corpus work: 9ed89dac-bc72-527a-a68d-313710362187
DOI: 10.12688/wellcomeopenres.16544.2

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