Article

A genomic-led strategy to anticipate drug safety effects

2025-09-14

Abstract excerpt

Safety-related issues account for approximately 28% of failures in new drug discovery programs. On top of that, many are discovered during post-marketing surveillance, significantly limiting drug utility and application. To proactively address these concerns, we developed a genetics-led strategy leveraging Mendelian Randomization (MR) across large-scale genetic datasets from the Million Veteran Program, FinnGen, a...

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Literature Corpus work: f85c7f54-fb44-57b9-b6d4-e29c4009591c
DOI: 10.1101/2025.09.11.25335448

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