Article
DMRdb: a disease-centric Mendelian randomization database for systematically assessing causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases.
Nucleic acids research - 6 Jan 2025
Zheng Xiao, Tian Zhihao, Che Xiaohui, Zhang Xu, Xiang Yu, Ge Zhijian, Zhai Zhaoyu, Ma Qinfeng, Pan Jianbo
Abstract excerpt
Exploring the causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases is fundamental to the life sciences. However, large-scale research using Mendelian randomization (MR) analysis is currently lacking. To address this, we introduce DMRdb (http://www.inbirg.com/DMRdb/), a disease-centric Mendelian randomization database, designed to systematically assess causal...
Topics
- Humans
- Mendelian Randomization Analysis
- Quantitative Trait Loci
- Genome-Wide Association Study
- CpG Islands
- Databases, Genetic
- DNA Methylation
- Disease
- Genetic Predisposition to Disease
- Proteins