Article

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

2020-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of MYB transcriptional co-activator complex. By rapid and selective peptidomimetic interference with the binding of CBP/P300 to MYB, but not CREB or MLL1, we find that the leukemic functions of MYB are mediated by C...

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Literature Corpus work: e48a4750-cd60-5f10-84de-4054b7e3e04e
DOI: 10.1101/2020.05.05.077156

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