Article
Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia.
Cell reports - 29 Sept 2020
Miyamoto Ryo, Okuda Hiroshi, Kanai Akinori, Takahashi Satoshi, Kawamura Takeshi, Matsui Hirotaka, Kitamura Toshio, Kitabayashi Issay, Inaba Toshiya, Yokoyama Akihiko
Abstract excerpt
Uncontrolled self-renewal of hematopoietic progenitors induces leukemia. To self-renew, leukemia cells must continuously activate genes that were previously active in their mother cells. Here, we describe the circuitry of a transactivation system responsible for oncogenic self-renewal. MLL recruits RNA polymerase II (RNAP2) to unmethylated CpG-rich promoters by its CXXC domain and activates transcription by...
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