Article

Peptidomimetic blockade of MYB in acute myeloid leukemia

2017-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant gene expression is a hallmark of acute leukemias. However, therapeutic strategies for its blockade are generally lacking, largely due to the pharmacologic challenges of drugging transcription factors. MYB-driven gene trans-activation with CREB-binding protein (CBP)/P300 is required for the initiation and maintenance of a variety of acute lymphoblastic and myeloid leukemias, including re...

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Literature Corpus work: fe40669d-08d5-50ab-8815-5ffe93a44df5
DOI: 10.1101/222620

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