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Article

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes.

Blood - 24 Apr 2014

Pattabiraman Diwakar R, McGirr Crystal, Shakhbazov Konstantin, Barbier Valerie, Krishnan Keerthana, Mukhopadhyay Pamela, Hawthorne Paula, Trezise Ann, Ding Jianmin, Grimmond Sean M, Papathanasiou Peter, Alexander Warren S, Perkins Andrew C, Levesque Jean-Pierre, Winkler Ingrid G, Gonda Thomas J

Abstract excerpt

The MYB oncogene is widely expressed in acute leukemias and is important for the continued proliferation of leukemia cells, suggesting that MYB may be a therapeutic target in these diseases. However, realization of this potential requires a significant therapeutic window for MYB inhibition, given its essential role in normal hematopoiesis, and an approach for developing an effective therapeutic. We previously...

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Share to Gene Expression Regulation, Leukemic
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mice, Mutant Strains

Share to Oncogene Proteins, Fusion

Share to Oncogenes

Share to p300-CBP Transcription Factors

Share to Proto-Oncogene Proteins c-myb

Source

Identifiers

PMID: 24596419
DOI: 10.1182/blood-2012-02-413187

Genes

MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes.PMID 24596419Read ↗

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