Article
Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction
3 Dec 2015
Abstract excerpt
The transcription factor Myb plays a key role in the hematopoietic system and has been implicated in the development of leukemia and other human cancers. Inhibition of Myb is therefore emerging as a potential therapeutic strategy for these diseases. However, because of a lack of suitable inhibitors, the feasibility of therapeutic approaches based on Myb inhibition has not been explored. We have identified the...
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