Article

Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

2022-12-22

Abstract excerpt

<h4>Background</h4> Marfan syndrome (MFS), an inherited disorder caused by FBN1 gene mutations, causes fatal aortic aneurysm. Selective angiotensin II (Ang II) type 1 (AT 1 ) receptor blockade is a preventive option for patients with MFS aortopathy, and recent clinical studies demonstrated that the inhibitory effect of an AT 1 receptor blocker (ARB) losartan on aortic aneurysm growth is equivalent to that of β...

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Literature Corpus work: d89e9f7b-40f1-5578-b3af-e452c227578f
DOI: 10.1101/2022.12.21.521508

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