Article
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Science (New York, N.Y.) - 7 Apr 2006
Habashi Jennifer P, Judge Daniel P, Holm Tammy M, Cohn Ronald D, Loeys Bart L, Cooper Timothy K, Myers Loretha, Klein Erin C, Liu Guosheng, Calvi Carla, Podowski Megan, Neptune Enid R, Halushka Marc K, Bedja Djahida, Gabrielson Kathleen, Rifkin Daniel B, Carta Luca, Ramirez Francesco, Huso David L, Dietz Harry C
Abstract excerpt
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor-beta (TGF-beta) family of cytokines. We show that aortic aneurysm in a mouse model of MFS is associated with increased TGF-beta signaling and can be prevented by TGF-beta...
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