Numerical knockouts–In silico assessment of factors predisposing to thoracic aortic aneurysms

Abstract excerpt

Myriad risk factors-including uncontrolled hypertension, aging, and diverse genetic mutations-contribute to the development and enlargement of thoracic aortic aneurysms.Detailed analyses of clinical data and longitudinal studies of murine models continue to provide insight into the natural history of these potentially lethal conditions.Yet, because of the coexistence of multiple risk factors in most cases, it has...

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