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Article

The fibrillin-1 gene: unlocking new therapeutic pathways in cardiovascular disease.

Heart (British Cardiac Society) - 1 Jan 2013

Barrett Paddy M, Topol Eric J

Abstract excerpt

The dramatic reductions in DNA sequencing costs allow us to delve deeper into the genomic alterations that increase susceptibility to many polygenic cardiovascular diseases. One such condition is an abnormal proximal aorta. Until recently, many believed that dilated, distorted or dissected proximal aortas might represent a forme fruste of Marfan syndrome or a continuum of aortopathy. Although an FBN-1 mutation...

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Identifiers

PMID: 22942299
DOI: 10.1136/heartjnl-2012-301840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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