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Article

[Novel pharmacological strategies for aortic dilation in Marfan syndrome: from mouse models to human patients].

Giornale italiano di cardiologia (2006) - 1 Jan 2000

Perrino Cinzia, Schiattarella Gabriele Giacomo, Bottino Roberta, Magliulo Fabio, Oliveti Marco, Esposito Giovanni, Trimarco Bruno

Abstract excerpt

Marfan syndrome (MS) is a congenital disorder of the connective tissue characterized by aortic dilation with frequent progression to aortic aneurysms requiring surgical intervention. Although mutations in the fibrillin-1 (FBN1) gene have been recognized as the genetic cause of MS a long time ago, only recently deeper knowledge of the molecular mechanisms underlying fibrillin-1 biology and the crucial role of...

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Source

Identifiers

PMID: 25174594
DOI: 10.1714/1596.17416

Genes

FBN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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