Article

Blocking Compensatory Matrix Cross-Linking Accelerates Thoracic Aortopathy in a Mouse Model of Marfan Syndrome

2026-08-25

Abstract excerpt

Mechanical homeostasis plays a central role in promoting and preserving optimal structure and function in the adult aorta. Although pathogenic variants can compromise homeostatic processes, it appears that intramural cells yet attempt to compensate for some genetically induced changes. In particular, lysyl oxidase is higher in the adult Marfan aorta compared with the age-matched control aorta. Here, we block lysyl...

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Literature Corpus work: 97bfaedf-6257-5911-9291-9578901c2a41
DOI: 10.64898/2026.08.24.746812

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