Article

Imaging-Based Age- and Sex-specific Cardiovascular and Skeletal Phenotypes in <i> Fbn1 <sup>C1041G/+</sup> </i> Mice

2026-07-24

Abstract excerpt

Marfan syndrome is a multisystem connective tissue disorder with age-dependent and sex-dependent phenotypic variability. This study characterized early cardiovascular, valvular, transmitral flow, and skeletal changes in Fbn1 C1041G/+ mice. Male and female wild-type and Fbn1 C1041G/+ mice were examined from 4 to 20 weeks of age. Transthoracic echocardiography was used to measure aortic root and ascending aortic...

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Literature Corpus work: 878fbda4-84fa-5d57-b7e0-2bccd469f188
DOI: 10.64898/2026.07.21.739835

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