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Article

Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.

American journal of human genetics - 4 Apr 2013

Watson Corey T, Steinberg Karyn M, Huddleston John, Warren Rene L, Malig Maika, Schein Jacqueline, Willsey A Jeremy, Joy Jeffrey B, Scott Jamie K, Graves Tina A, Wilson Richard K, Holt Robert A, Eichler Evan E, Breden Felix

Abstract excerpt

The immunoglobulin heavy-chain locus (IGH) encodes variable (IGHV), diversity (IGHD), joining (IGHJ), and constant (IGHC) genes and is responsible for antibody heavy-chain biosynthesis, which is vital to the adaptive immune response. Programmed V-(D)-J somatic rearrangement and the complex duplicated nature of the locus have impeded attempts to reconcile its genomic organization based on traditional B-lymphocyte...

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Source

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Identifiers

PMID: 23541343
DOI: 10.1016/j.ajhg.2013.03.004
PMCID: PMC3617388

Genes

IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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