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Predicting the most deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) of HRAS gene and in silico evaluation of their structural and functional consequences towards diagnosis and prognosis of cancer

2022-06-13

Abstract excerpt

Harvey rat sarcoma (HRAS) protooncogene belongs to the RAS family and is one of the pathogenic genes that cause cancer. Deleterious nsSNPs might have adverse consequences at the protein level. This study aimed to investigate deleterious nsSNPs in the HRAS gene in predicting structural alterations associated with mutants that disrupt normal protein-protein interactions. Functional and structural analysis was em[loy...

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Literature Corpus work: e42b02d9-e01e-5abc-b1f8-88caa22240cd
DOI: 10.21203/rs.3.rs-1683286/v1

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