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Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays.

Scientific reports - 9 Aug 2021

Khoruddin Nurul Ain, Noorizhab Mohd NurFakhruzzaman, Teh Lay Kek, Mohd Yusof Farida Zuraina, Salleh Mohd Zaki

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) are the most common genetic variations for various complex human diseases, including cancers. Genome-wide association studies (GWAS) have identified numerous SNPs that increase cancer risks, such as breast cancer, colorectal cancer, and leukemia. These SNPs were cataloged for scientific use. However, GWAS are often conducted on certain populations in which the Orang Asli and...

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PMID: 34373545
DOI: 10.1038/s41598-021-95618-y
PMCID: PMC8352870

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