Article

Programming cell behavior with synthetic protease-activated receptors

2026-06-08

Abstract excerpt

Extracellular proteases are important signaling molecules in coagulation, inflammation, cell migration, and pain. Dysregulation of extracellular protease activity is common in diseases that perturb these critical functions. Engineering cells to sense and respond programmatically to protease activity has applications in biosensing, cell-based screening for protease activity, and therapeutics. Here we report synthet...

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Literature Corpus work: e41b1667-e15b-5d75-8297-d7a04f82f807
DOI: 10.64898/2026.06.07.730697

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