Article

Geometric regulation of histone state directs melanoma reprogramming

2019-12-11

Abstract excerpt

Malignant melanoma displays a high degree of cellular plasticity during disease progression, making classification of the heterogeneous population and selection of an appropriate therapy challenging. Signals in the tumor microenvironment are believed to influence melanoma plasticity through changes in the epigenetic state to guide dynamic differentiation and de-differentiation events that underlie tumorigenicity a...

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Literature Corpus work: e40ee397-907e-563a-b88e-513fb0ff012d
DOI: 10.1101/872226

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