Article
Mechanical confinement governs phenotypic plasticity in melanoma.
Nature - 1 Nov 2025
Hunter Miranda V, Joshi Eshita, Bowker Sydney, Montal Emily, Ma Yilun, Kim Young Hun, Yang Zhifan, Tuffery Laura, Li Zhuoning, Rosiek Eric, Browning Alexander, Moncada Reuben, Yanai Itai, Byrne Helen, Monetti Mara, de Stanchina Elisa, Hamard Pierre-Jacques, Koche Richard P, White Richard M
Abstract excerpt
Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes: proliferative versus invasive states1,2. Although it has long been hypothesized that such switching is triggered by external cues, the identity of these cues remains unclear. Here we demonstrate that mechanical confinement mediates phenotype switching through chromatin remodelling. Using a...
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