Article

Dynamical modelling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity

2023-01-10

Abstract excerpt

<h4>ABSTRACT</h4> Phenotypic heterogeneity of melanoma cells contributes to drug tolerance, increased metastasis, and immune evasion in patients with progressive disease. Diverse mechanisms have been individually reported to shape extensive intra- and inter-tumoral phenotypic heterogeneity, such as IFNγ signaling and proliferative to invasive transition, but how their crosstalk impacts tumor progression remains l...

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Literature Corpus work: e9437a97-5b83-5a63-98cd-28a7db221b96
DOI: 10.1101/2023.01.09.523355

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