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Article

ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions

22 Mar 2024

Abstract excerpt

Cell plasticity sustains intra-tumor heterogeneity and treatment resistance in melanoma. Deciphering the transcriptional mechanisms governing reversible phenotypic transitions between proliferative/differentiated and invasive/stem-like states is required. Expression of the ZEB1 transcription factor is frequently activated in melanoma, where it fosters adaptive resistance to targeted therapies. Here, we performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38519642
DOI: 10.1038/s41388-024-03010-7

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