Article

ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions

2023-02-10

Abstract excerpt

Cell plasticity sustains intra-tumor heterogeneity and treatment resistance in melanoma. Deciphering the transcriptional mechanisms governing reversible phenotypic transitions between proliferative/differentiated and invasive/stem-like states is required. Expression of the ZEB1 transcription factor is frequently activated in melanoma, where it fosters adaptive resistance to targeted therapies. Here, we performed a...

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Literature Corpus work: 79368b2d-581c-512c-bf8b-14e76fe9b348
DOI: 10.1101/2023.02.10.526467

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