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Article

Geometric regulation of histone state directs melanoma reprogramming

3 Jul 2020

Abstract excerpt

Malignant melanoma displays a high degree of cellular plasticity during disease progression. Signals in the tumor microenvironment are believed to influence melanoma plasticity through changes in the epigenetic state to guide dynamic differentiation and de-differentiation. Here we uncover a relationship between geometric features at perimeter regions of melanoma aggregates, and reprogramming to a stem cell-like...

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PMID: 32620903
DOI: 10.1038/s42003-020-1067-1

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