Article

Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma

2025-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Localized cutaneous melanoma can be cured by excision but success critically depends on early detection and risk assessment of primary lesions. However, their initiation, progression, and immunology remain poorly understood, partly due to high intra- and inter-tumor heterogeneity. We studied this heterogeneity using spatial profiling in over 300 histological domains, each representing a single p...

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Literature Corpus work: c721ea75-92d3-598c-89e2-614877bfe644
DOI: 10.1101/2025.06.21.660851

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