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Article

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.

Genome research - 1 Jan 2012

Axelsson Erik, Webster Matthew T, Ratnakumar Abhirami, Ponting Chris P, Lindblad-Toh Kerstin

Abstract excerpt

Analysis of diverse eukaryotes has revealed that recombination events cluster in discrete genomic locations known as hotspots. In humans, a zinc-finger protein, PRDM9, is believed to initiate recombination in >40% of hotspots by binding to a specific DNA sequence motif. However, the PRDM9 coding sequence is disrupted in the dog genome assembly, raising questions regarding the nature and control of recombination...

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Share to GC Rich Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genomic Instability

Share to Histone-Lysine N-Methyltransferase

Share to Polymorphism, Single Nucleotide

Share to Recombination, Genetic

Source

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Identifiers

PMID: 22006216
DOI: 10.1101/gr.124123.111
PMCID: PMC3246206

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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