Article

High prevalence of Prdm9-independent recombination hotspots in placental mammals

2023-11-17

Abstract excerpt

In many mammals, recombination events are concentrated into hotspots directed by a sequence specific DNA-binding protein named Prdm9. This protein facilitates chromosome pairing and its inactivation has been shown to induce fertility losses in mice and rats. Intriguingly, Prdm9 has been lost several times in vertebrates, and notably among mammals, it has been pseudogenized in the ancestor of canids (dogs, wolves...

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Literature Corpus work: c717a0dc-704b-56c6-b33c-9b3033b2c583
DOI: 10.1101/2023.11.17.567540

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