Article
A combination of cis and trans control can solve the hotspot conversion paradox.
Genetics - 1 Mar 2008
Peters A D
Abstract excerpt
There is growing evidence that in a variety of organisms the majority of meiotic recombination events occur at a relatively small fraction of loci, known as recombination hotspots. If hotspot activity results from the DNA sequence at or near the hotspot itself (in cis), these hotspots are expected to be rapidly lost due to biased gene conversion, unless there is strong selection in favor of the hotspot itself....
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