Article

Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis

2024-09-26

Abstract excerpt

<title>Abstract</title> <p>The increasing prevalence of antimicrobial resistance is an important challenge that warrants new approaches to antibiotic development. Currently, all antibiotics inhibit biological processes. To explore whether activation of a biochemical pathway can elicit bactericidal effects we engineered variants of Mycobacterium tuberculosis ATP-phosphoribosyltransferase (ATP-PRT) that are resista...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3ec4b25-85fd-53d5-a7bf-72d14d327652
DOI: 10.21203/rs.3.rs-5010166/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosisDOI 10.21203/rs.3.rs-5010166/v1Read

Identifying a novel mechanism of L-leucine uptake in <i>Mycobacterium tuberculosis</i> using a chemical genomic approachSemantic proximity Read

KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Deciphering the transcriptomic landscape of pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

<i>α</i> -Aminooxyacetic acid derivatives acting as pro-drugs against <i>Mycobacterium tuberculosis</i>Semantic proximity Read

A chemical-genetic map of the pathways controlling drug potency in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.Semantic proximity Read

<i>Mycobacterium tuberculosis</i> requires conditionally essential metabolic pathways for infectionSemantic proximity Read

Orthogonal perturbation of sulfur availability reveals antibiotic-induced synthetic lethality in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

KatG catalase deficiency confers bedaquiline hyper-susceptibility to isoniazid resistant <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Pathogenic mycobacteria suppress host antimicrobial peptides by dehydrogenating L-alanineSemantic proximity Read

Metabolic control of drug resistance by a mycobacterial ion channelSemantic proximity Read

Role of post‐translational modifications in the acquisition of drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read