Article

Pathogenic mycobacteria suppress host antimicrobial peptides by dehydrogenating L-alanine

2023-09-22

Abstract excerpt

<title>Abstract</title> <p>Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by <italic>Mtb</italic> (<italic>Mycobacterium tuberculosis</italic>), but the underlying mechanism remains unknown. Here, we report that L-alanine interacted with PRSS1 and unfroze the inhibitory effect of PRSS1 on the activation of NF-κB pathway to induce the expression of AM...

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Literature Corpus work: 9cc65a74-c8ca-5b99-9bb1-9f8af8178ea5
DOI: 10.21203/rs.3.rs-3367542/v1

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